3,3′-Diindolylmethane (DIM) is a molecule named after its structure in which two indole groups are connected to a methyl group. It is commonly found in broccoli and is expected to be an anti-cancer molecule and aromatase inhibitor. It has a strong effect on estrogen metabolism and can maintain the relative balance of the body (by preventing a sharp increase or decrease in estrogen). DIM also exerts numerous anti-cancer effects in the body and is one of the reasons why this vegetable family is considered healthy. It has been pointed out that the aryl hydrocarbon receptor (AhR) has a role in some immune cells, and the activation of this receptor in natural killer (NK) cells (observed with 10μM 3,3′-diindolylmethane) can increase IFN- γ and effector functions, thereby increasing their inhibitory effect on the growth of cancer cells.

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Function of 3,3′-Diindolylmethane

1. It is abnormal growth of cells of the cervix (cervical dysplasia).

2. It can Prevent breast cancer.

3. It can Prevent uterine cancer.

4. It can Prevent colon cancer.

5. It can Prevent prostate enlargement (benign prostatic hypertrophy, BPH).

6. It can Prevent treat premenstrual syndrome (PMS).